Myelopoiesis

Dysplastic myelopoiesis includes hypogranulation (best seen in mature granulocytes in the bloodsmear), hypolobulation of the granulocytes and an abnormal chromatin condensation which is more coarse and clumpy.

In the bone marrow aspiration degranulation can be seen throughout the myelopoiesis. More mature myelopoiesis is showing similar abnormal nucleus formation (abnormal clumpy chromatin condensation, hyposegmentation) as is seen in the blood smear.

Dysplastic features can also be seen due to intoxication, medication, nutrition deficiencies, so care must be taken mentioning myelodysplasia and all other possible causes should first be excluded.