Adult T-cell Lymphoma/Leukemia (ATLL)

Cells can show several morphological variants,; medium to large cell type, pleomorphic small type, large multilobulated, deeply convoluted cell type.
Most commonly found in peripheral blood and bone marrow are cells with bizarre hyperlobated nuclei, condensed chromatin and “flower cells”, often resembling Sézary cells.
By flowcytometry the cells are positive for CD3 (usually weak), CD4, CD5 and CD25, negative for CD7 and CD8