Chronic Myelomonocytic Leukemia (CMML)

CMML is a clonal hematopoietic stem cell disorder characterized by the presence of sustained (>3 months) peripheral blood monocytosis (≥1 × 109/L and monocytes ≥10% of white blood cell count) along with dysplastic features in one or more lineages the bone marrow. Both myeloid and monocytic lineages are involved. Hypogranulation makes differentiation between promyelocytes and promonocytes often difficult.

Diagnostic criteria