AML with t(8;21)(q22;22)

Most common morphological features of AML with t(8;21)(q22;q22) are large blasts with abundant basophilic cytoplasm, often containing azurophilic granules and a perinuclear clearing. Auer rods are found frequently and are long, sharp and tapered and can even be found in matured neutrophils. Some blasts may show large granules, resembling those found in Chédiak-Higashi. Maturing neutrophil precursors with peripheral cytoplasmic basophilia are found, just like in acute myeloid leukemia with neutrophilic maturation.
CD34 expression is strong, HLA-Dr, MPO and CD13 are positive, and CD33 expression is weak. Co-expression with CD19 and/or cyCD79a is frequent.