APL variant with PML-RARA

The microgranular (hypogranular) variant APLv more often has a high white bloodcell count at presentation, the blasts typically have a bilobed or folded nucleus and no apparent granules. Morphologically this variant can easily be misdiagnosed for AML with FLT3 ITD (“AML-cuplike”) or AML myelomonocytic.
Phenotyping is similar to that of APL-RARA, but the variant frequently coexpresses CD2 and in some cases CD56.