WHO classification for MPAL

 

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Lineage
Markers
B-lineage strong CD19 combined with at least 1 of the following markers: strong cyCD79a, strong cyCD22 or strong CD10
  OR
 
weak CD19 combined with at least 2 of the following markers: strong cyCD79a, strong cyCD22 or strong CD10


T-lineage strong cyCD3 or sCD3


Myeloid-lineage MPO positive (by flowcytometry, immunohistochemistry or enzym cytochemistry)
  OR
 
monocytic differentiation: at least 2 of the following positive: NSE cytochemistry, CD11c, CD14, CD64, lysozyme